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The current first line of treatment for DN is a tight glycemic control combined with reninangiotensinaldosterone system modulators, 3 but in most cases, renal function continues to deteriorate, leading to renal failure

doi: 10.1001/jama.2015.9676 [DOI] [PubMed] [Google Scholar] 32.Blackman A, Foster GD, Zammit G, et al

These enforcement actions underscore the importance of verification

Clinical practice guidelines suggest several scenarios where dose modification may be appropriate: Persistent gastrointestinal symptoms lasting beyond the first week of a new dose level may warrant extending that dose phase by an additional 2-4 weeks before further escalation