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However, some people have difficulty absorbing vitamin B12 from their diet, including dietary restrictions, certain medical conditions like pernicious anemia, or medications that interfere with B12 absorption

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doi:10.1128/AEM.02173-12

First Human Niagen Study That Demonstrates Effectiveness: A study published in Nature Communications in 2016 reports that single oral doses of 100mg, 300mg, and 1,000mg of Niagen can safely elevate NAD+ levels. Researchers investigated the effects of NR supplementation in 12 healthy men and women, establishing both its safety and efficacy as an NAD+ precursor in humans