semaglutide vs keto Ozempic for Weight Loss, What to Know Keto and Ozempic: Safety, Metabolic

Qiu, Shidong, et al

Gallstone formation, medically called cholelithiasis, occurs in roughly 12% of GLP-1 users, primarily because fast fat mobilization from the liver increases cholesterol concentration in bile

NICE guidelines for type 2 diabetes (NG28) recommend reviewing GLP-1 treatment at around 6 months and continuing only if there has been a meaningful reduction in HbA1c (typically at least 11 mmol/mol [1%]) and weight loss of at least 3% of initial body weight

Treatment with liraglutide injection 1.2 mg and 1.8 mg as add-on to metformin resulted in a significant mean HbA1c reduction relative to placebo add-on to metformin and resulted in a similar mean HbA1c reduction relative to glimepiride 4 mg add-on to metformin (Table 4)