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When to Consider Dosing Adjustments or Medication Alternatives If nausea persists despite dietary changes and extended titration periods, your provider may recommend dose reduction, extended intervals between injections, or switching between GLP-1 medications

Meta-analyses show that semaglutide increases the likelihood of discontinuing treatment (relative risk 1.67, 95% CI 1.27-2.21), primarily due to gastrointestinal adverse events like nausea, vomiting, and diarrhea

So, to avoid too much caffeine, make sure you check the labels of anything you eat or drink in the 4-6 hours between finishing your workout and heading to bed