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While GIPR agonism appears to enhance the efficacy of GLP-1R agonism for glucose control and weight loss, its impact on the antiinflammatory actions of GLP-1R agonism is less clear

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Segmented filamentous bacteria ( SFB ) in the mouse gut promote the production of IL-17 and IFN- and play key roles in both osteoclast and osteoblast formation (221223), indicating that the GM modulates bone metabolism by altering the host immune status