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The strongest clinical evidence: a 2019 randomized, double-blind 12-week trial in the British Journal of Dermatology (n=44) found 0.5% bakuchiol and 0.5% retinol produced comparable reductions in wrinkle surface area and hyperpigmentation, with retinol users reporting significantly more facial scaling and stinging

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In addition, the Western blot analysis further showed that the HFD-induced suppression of IR, IRS-1, p-AMPK, and p-ACC expression in the liver was also altered by NaB (Fig