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for some [dulaglutide (Gerstein et al., 2019), liraglutide (Marso et al., 2016) and semaglutide (Marso et al., 2017)], the CVOTs also confirmed a cardiovascular benefit and eventually led to the approved use of these GLP-1 RAs to reduce cardiovascular risk in people with type 2 diabetes and established CVD or at high cardiovascular risk (Honigberg et al., 2020)

Although the molecular mechanism(s) underlying the association between intestinal NAD + biology and homeostasis remains enigmatic, AMPK has been demonstrated to upregulate NAMPT, boosting NAD + biosynthesis and SIRT activity [88,89,90]

DAgati, V

Publication bias was assessed with the Egger test [20]