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Many adults and children with B12 deficiency report experiencing paresthesia, a burning or pinprick sensation in certain parts of the body, such as the hands and feet

Diurnal variations in plasma concentrations of basic and neutral amino acids and in red cell concentrations of aspartate and glutamate: effects of dietary protein intake

doi: 10.1007/s40265-019-01192-z 46 DuftonNHannonRBrancaleoneVDalliJPatelHBGrayMet al

Their ability to disrupt the blood-brain barrier, communicate with microglia, and respond to a wide array of environmental and psychosocial triggers makes them powerful amplifiers of neuroimmune dysfunction