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Impact of GLP-1RA on atherosclerotic plaques in T2D patients GLP-1 receptor agonists (GLP-1RAs) may mitigate these risks by inhibiting coronary lesion progression through anti-inflammatory and anti-proliferative effects, stabilizing the vascular environment, and addressing systemic atherosclerosis

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This review delineates the multifaceted mechanisms by which GLP-1RAs exert ocular benefits, including retinal ganglion cell (RGC) rescue via calcium channel and GABAergic modulation, mitochondrial protection through PINK1/Parkin-mediated mitophagy and ERK1/2-HDAC6 signaling, as well as potent anti-inflammatory effects via cytokine reduction and immune cell recruitment inhibition