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MTHFR 677 is in exon 4, where cytosine (C) is replaced by thymine (T), and the corresponding alanine is changed to valine

Reczek CR, Chandel NS (2015) ROS-dependent signal transduction

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Interaccin con drogas/frmacos El metotrexato, un medicamento utilizado en el tratamiento del cncer, la psoriasis, y la artritis reumatoide, inhibe la enzima dihidrofolato reductasa y, por lo tanto, limita la disponibilidad de grupos metilo donados a partir de derivados de folato