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Participants taking the highest dose lost an average of 28.7% of their body weight over 68 weeksroughly 60 to 71 pounds for many participants

Stay away from the inner thigh, which has more nerve endings and blood vessels

A previous study highlighted that they increase nitric oxide production, reduce oxidative stress and promote microvascular recruitment, including in the retina and optic nerve, through direct actions on vascular endothelium

Compounded options: Compounded Semaglutide Injections (starting at $299/month) Compounded Tirzepatide Injections (starting at $399/month) GLP-1 Liquid Drops GLP-1 Lozenges Oral Semaglutide Liposomal Tablets FDA-approved options: Wegovy Pen (once-weekly injection, starting at $199/month through Shed) Wegovy Pill / Foundayo (once-daily oral tablet, starting at $149/month) Zepbound (via LillyDirect after provider approval) The needle-free formats, including drops, lozenges, and oral tablets, are particularly relevant for people who find injections to be a significant barrier