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At the same time, B12 insufficiency in the liver leads to shrinking of the intestinal cells and malabsorption of nutrients (including B12 itself), leading to a cycle of worsening B12 deficiency

Hydroxocobalamin binds well with blood proteins, allowing it to stay in the body longer than other forms

This matters especially when you have: B12 (methylcobalamin vs cyanocobalamin) Folate (methylfolate vs folic acid) These bioactive forms help people with MTHFR gene variants (6-14% of the population) [24]

The right format is simply whichever you can stay consistent with, and our team will help you settle on a rhythm that fits your week