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solo estn para uso tpico, que es mucho menos eficaz actualmente se ha solicitado autorizacin a la Agencia Espaola de Medicamentos y Productos Sanitarios (AEMPS) pero todava no hay resolucin al respecto

GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]

A cutoff value of 20 s was used to prevent tissue damage