Elucidation of the anticancer mechanism of durian fruit ( Durio zibethinus ) pulp extract in human leukemia (HL-60) cancer cells
If pain causes you to stop breathing in mid-inspiration, the Murphy sign is positive
Contact your GP or diabetes specialist nurse if : Fatigue is severe, persistent, or worsening despite adequate rest and nutrition You experience symptoms of hypoglycaemia such as confusion, sweating, trembling, or rapid heartbeat Fatigue is accompanied by unexplained weight loss beyond what is expected with Ozempic treatment You develop signs of dehydration including dark urine, dizziness, or reduced urine output You notice yellowing of the skin or eyes (jaundice), which could indicate liver or gallbladder problems You experience new or worsening vision changes, floaters, or blurred vision , which may relate to diabetic retinopathy complications Fatigue is associated with severe abdominal pain , particularly if radiating to the back, which may suggest pancreatitis Seek urgent medical care (call 111 or attend A&E) for : Severe, persistent abdominal pain Inability to keep fluids down due to vomiting Significant visual changes Call 999 immediately for : Chest pain Severe shortness of breath Palpitations with dizziness or fainting Your healthcare provider may wish to perform investigations to rule out other causes of fatigue, such as: Blood tests to check full blood count (for anaemia), thyroid function, vitamin B12 and folate levels, kidney and liver function, and electrolytes HbA1c measurement to assess overall glycaemic control Review of all medications to identify potential drug interactions or cumulative side effects According to NICE guidance (NG28) on type 2 diabetes management, regular monitoring and medication review are essential components of safe prescribing
The higher dose in months 2 and 3 is where most of the measurable body composition change occurs
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