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Those with certain FTO variants may require higher exercise volumes or strength training emphasis to prevent metabolic adaptation as weight decreases

In models of hypertension, BPC-157 showed blood pressure-lowering effects, while in hypotensive states, it supported pressure normalization, suggesting homeostatic regulation rather than unidirectional cardiovascular effects

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10.1038/s41598-017-10524-6 Summary Keywords valproic acid, acylcarnitines, fatty acid -oxidation, peroxisome proliferator-activated receptor , hepatotoxicity Citation Ma Y, Wang M, Guo S, Li T, Liu X and Zhao L (2022) The serum acylcarnitines profile in epileptic children treated with valproic acid and the protective roles of peroxisome proliferator-activated receptor a activation in valproic acid-induced liver injury