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doi: 10.3389/fmicb.2021.622091 89

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Purification reaction After the cyclization reaction is completed, column chromatography is performed to obtain purified Melanotan

The pancreatic-endocrine-osseous axis involves a potential link between DPP-4, bone, and energy metabolism through the receptor activator of nuclear factor kappa B ligand (RANKL), which induces DPP-4 expression in osteoclasts, leading to decreased GLP-1 levels and increased blood glucose levels