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[5] Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X chromosome in certain cells creates a population of G6PD-deficient red blood cells coexisting with unaffected red blood cells

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In Drosophila and mammalian systems alike, clock proteins such as PER, tim, and CRY are rhythmically ubiquitinated and degraded, a process that defines the length of the circadian period by delaying or advancing the feedback inhibition phase (Vriend and Reiter, 2015