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In the female offspring, mitochondrial fusion markers on P1 suggest increased mitochondrial regeneration, while in adults increased mitochondrial fission and autophagosome markers were observed, with high levels of MnSOD and OXPHOS complex I suggesting an increase in energy demand and oxidative stress, thereby more mitochondrial turnover (Twig et al., 2008

TNF- inhibitors, therefore, may serve as an effective therapeutic strategy for attenuating disease progression in severe SARS-CoV-2 infection