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Description

This modification is shared with tirzepatide and other modern incretin analogs, and is essential for achieving the extended duration of action required for once-weekly dosing

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Each escalation step can temporarily increase side effects

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Glucagon levels in the liver's portal circulation regulate this signaling

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PMID: 40291085 | doi:10.1080/08998280.2025.2456441 Coskun T et al

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