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Using a weighted time-dependent Cox regression with randomized treatment, SGLT2i use during the study, and the interaction of randomized treatment by SGLT2i use during the study as categorical fixed factors, the HR for the primary outcome was 0.86 (95% CI, 0.701.06) for those with any SGLT2i use during the study and 0.81 (95% CI, 0.700.93) for those with no SGLT2i use

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In addition, it protects the organs against a cytokine overproduction, regulating the immune response and buffering oxidative damage

The results of our study also strengthened the results of previous studies where peak alkaline phosphatase levels were observed in pubertal phase of skeletal maturation in comparison to post pubertal phases 33,34,35