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As a clinically approved drug, the normal dosage of Epalrestat for adults is 150 mg per day, and in current study, to explore the influence of this dosage of Epalrestat on the development of RA, we specifically use a dose of 15.5 mg/kg according to the principle of dose conversion between animal and human [96]

CJC-1295 with DAC is dosed once or twice weekly at 1 to 2 mg