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Yes, B12 can interact with some medications

The WHO The World Health Organisation states the following in their document Mental health and psychosocial considerations during the COVID-19 outbreak The following directives are appropriate for those with B12 deficiency

Vitamin B 12 is needed to prevent anemia, since making porphyrin and heme in mitochondria for producing hemoglobin in red blood cells depends on succinyl-CoA made by vitamin B 12