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Further experimental and clinical trials are now needed to confirm this hypothesis and to clarify the molecular mechanisms underlying hyperhomocysteinemia-induced vascular disease

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When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases

However, in some cases, treatment may not be effective for individuals who have certain genetic disorders or other underlying health conditions