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Although phase-2 studies indicated some positive outcomes of ipamorelin for this condition, the benefits observed over 7-10 days were not considered substantial, leading to the discontinuation of clinical development [14, 15]

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One significant finding is from the SELECT trial, which showed that long-term use of semaglutide in individuals with obesity but without diabetes led to a 20% reduction in major cardiovascular events and an average weight loss of 9.4%