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Interestingly, mice treated with either semaglutide or dapagliflozin display intermediate values for these markers, suggesting a potential impact of these treatments on metabolic parameters

The E3 ubiquitin ligase RNF20 catalyzes H2Bub1, suppressing the transcription of ATG and thereby inhibiting autophagy

It also suppresses systemic inflammation and exerts a regulatory effect on the gut-brain-heart axis 60

We summarize the most promising noncoding RNAs that have been shown to regulate aging in recent years (Table 1) to provide a basis for screening agents that target lncRNAs to delay aging