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Speichinger, hormonal imbalances can be caused by a number of different health conditions: thyroid disease like hyperthyroidism or hypothyroidism, polycystic ovary syndrome (PCOS), primary ovarian insufficiency, and hyperprolactinemia, or having too much of a hormone called prolactin in your blood

Because this detoxification pathway relies heavily on glutathione, a deficiency means that histamine remains circulating in the bloodstream for prolonged periods

Med Chem 15:111 Liu J, Cao R, Yi W, Ma C, Wan Y, Zhou B, Ma L, Song H (2009) A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds