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Research-Only Designation Intended exclusively for laboratory use by qualified professionals

The choice often depends on whether the primary concern is local GI healing versus systemic chronic inflammation affecting multiple systems

Sleep 11(4):378387

Observational studies have tracked the effects of caloric restriction on lean, healthy individuals, and demonstrated that moderate restriction (2230% decreases in caloric intake from normal levels) improves heart function and reduces markers of inflammation (C-reactive protein, tumor necrosis factor [TNF]), risk factors for cardiovascular disease (LDL cholesterol, triglycerides, blood pressure), and diabetes risk factors (fasting blood glucose, insulin levels)