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Nitric oxide signaling connects the three systems, regulating blood flow and inflammatory responses across muscular, digestive, and neural tissue simultaneously

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Even under androgen deprivation therapy, androgen levels are sufficiently high to activate overexpressed AR, which is due to intratumoral in-situ synthesis 141 and residual synthesis in the adrenal gland 142 , along with decreased levels of the androgen inactivating enzymes CYP3A4, CYP3A5, and CYP3A7 in patient tissue samples 143

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