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1990) and by committee (ILAR 1980) or toxicologic pathology societies (Standardized System of Nomenclature and Diagnostic Criteria There is evidence from experimental studies documenting the regression of proliferative hepatocellular lesions including foci of cellular alteration, hepatocellular adenomas, and hepatocellular carcinomas following cessation of treatment (Maronpot 2009)

Some evidence suggests semaglutide may have slightly higher discontinuation rates due to GI symptoms compared to some other GLP-1 agonists, though this varies by dose and individual factors

As shown in Scheme 11

doi: 10.1038/s41580-020-00324-8