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It has emerged as a critical and rapidly growing public health concern, affecting an estimated 537 million individuals in 2022

The skins ability to retract depends on age, genetics, smoking history, skin elasticity, total weight loss, nutrition, and how long the skin was stretched before weight loss

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In addition, it inhibits inflammation and carcinogenesis, reinforces the colonic defense barrier, modulates gut epithelium permeability, promotes satiety, increases sodium and water reabsorption (anti-diarrheal agent) and reduces oxidative stress 4