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Notably, a systems biological assessment of immunity in patients with severe COVID-19 showed increased levels of bacterial DNA and lipopolysaccharide in the plasma 37 , which were positively correlated with the plasma levels of IL-6 as well as EN-RAGE, a biomarker of pulmonary injury that is implicated in the pathogenesis of sepsis-induced ARDS 38

Hence, it is interesting to investigate microbiota-mediated changes in vitamin D and B6 for effective diagnosis and management of IBS patients

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