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Activation of 3-AR via Gs cAMP PKA phosphorylation of hormone-sensitive lipase (HSL) leads to: Splitting of triglycerides into free fatty acids + glycerol Release of fatty acids from adipose tissue into the blood Increased oxidation of fatty acids in mitochondria (muscle, liver) Heffernan et al

Weight loss is not linear

On the formulation side, avoid mixing GHK-Cu with strong acids or vitamin C in the same injection session, as the peptide degrades at low pH

However, the CRR and overall response rate (ORR) of the RG7388 plus cytarabine group were higher than those of the RG7388 plus placebo group (CRR, 20.3% vs