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This bioactive molecule originates from catechin or epicatechin units which in turn constitute procyanidins that are highly abundant in the French maritime pine bark extract Pycnogenol (see sections 1.2.2 Pharmacodynamics, 4.1 Absorption into plasma/serum and concentration profiles, 5 Biodistribution, and 6.1 Pre-systemic metabolism: role of gut microbiota)

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It was firstly proved by Valadis group that plasma sEVs were uploaded siRNA through chemical transfection and electroporation and delivered the siRNA to monocytes and lymphocytes, leading to gene silencing of mitogen-activated protein kinase 1 (119)