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At this time, flumazenil is not Food and Drug Administration-approved nor guideline-recommended (AASLD 2014) for the treatment of HE, though it is mentioned as possible therapy in select cases pending further study

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In a model of traumatic brain injury in rats, allicin attenuated brain edema, neurological deficits, and apoptotic neuronal death, and exhibited antioxidant and anti-inflammatory effects, partly by increasing Akt-mediated eNOS activation (31)

Hepatic HDAC3 regulates systemic iron homeostasis and ferroptosis via the hippo signaling pathway