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Lysophosphatidylcholine acyltransferase-3 (LPCAT3) and acyl-CoA synthetase long chain family member 4 (ACSL4) are the crucial enzymes regulating PUFAs biosynthesis and remodeling by catalyzing AA to phospholipid (PL) hydroperoxide (PL-OOH, such as AA-OOH), which are considered specific biomarkers and drivers of ferroptosis (Xu et al., 2020