The activation phase, the second step in the canonical pathway, is driven by diverse stimuli such as K + efflux, ROS overproduction, lysosomal rupture, mitochondrial DNA (mtDNA) leakage, and organelle dysfunction (e.g., mitochondria, Golgi apparatus, endoplasmic reticulum) ( + efflux and thus canonical NLRP3 assembly, has also been suggested ( + efflux, which has been exclusively characterized in primary human and porcine monocytes
FDA recommends incorporating body composition metrics such as body fat percentage and skeletal muscle mass alongside traditional measures like total body weight as clinical endpoints
"Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement"
Balim Tezel (she/her) is a shopping updates editor at PS and the founder of Maison des Nus, a New York-based affordable luxury brand