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However, covalent modification of the 20S proteasome by MG reduces its degradation activity, leading to persistent activation of the unfolded protein response (UPR), which ultimately triggers apoptosis and inflammatory responses (129, 130)

Determination of L-carnitine acetyl-L-carnitine and propionyl-L-carnitine in human plasma by high-performance liquid chromatography after pre-column derivitization with l-aminoanthracene

The regulation of GLP-1 secretion both in humans [44] and at the cellular level [45] has been studied but, except for the finding that ingestion of whey protein as a preload 30 min before a meal augments the GLP-1 response, with clinical benefits for type 2 diabetes [46], it has been difficult to translate the knowledge gained into clinically relevant formulations