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In a multicentre, examiner-blind, clinical and neurophysiological study lasting 4 months, 120 hands from 82 patients with mild-to-moderate carpal tunnel syndrome were examined at baseline and 10, 60, and 120 days after treatment with 500 mg of acetyl-l-carnitine twice daily for 10 days intramuscularly followed by oral administration at 500 mg twice daily for 4 months