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Therapeutic potential of synthetic and natural iron chelators against ferroptosis

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The N-terminal -helix governs membrane-mediated aggregation by anchoring the protein into the membrane ( -helix formation followed by membrane damage have been observed for at least two other amyloidogenic proteins: -synuclein, linked to Parkinsons disease ( Mitochondrial dysfunction in the striatum is a primary feature of Huntingtons disease ( -helix in the synapses within the striatum is an important factor facilitating mitochondrial dysfunction

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