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Symptoms of Vitamin B12 Deficiency Some dont show any symptoms of a vitamin B12 deficiency, while others may experience: Diarrhea Constipation Tiredness Light-headedness Loss of appetite Pale skin Lack of focus Shortness of breath Swollen, red tongue Bleeding gums Long-term vitamin B12 deficiency can cause: Confusion Dementia Depression Loss of balance Numbness and tingling in your hands and feet Treatment of Vitamin B12 Deficiency Treatment involves raising your vitamin B12 levels and will vary based on the cause of your deficiency

TNF- results in insulin insensitivity, indirectly by stimulating stress hormone production and directly by sustained induction of SOCS-3 which decreases insulin-induced insulin receptor substrate 1 (IRS1) tyrosine phosphorylation and its association with the p85, regulatory subunit of phosphatidylinositol-3 kinase

Boyer JL

Wang X, Song R, Li Z