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The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for JANUMET XR and any potential adverse effects on the breastfed infant from JANUMET XR or from the underlying maternal condition

The risk of severe nausea, vomiting, and treatment discontinuation increases substantially when proper titration is not followed

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Furthermore, encouraging data from recent interventional studies favor the benefit of homocysteine-lowering therapy in the prevention and correction of vascular disorders related to elevated homocysteine levels