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The Most Important Insight: Its Often Indirect In clinical practice, when irritability shows up, it is usually not a direct drug effect on the brain

According to reports, the stimulation and maintenance of the myofibroblast phenotype are dependent on the transforming growth factor- (TGF-)/Smad, wingless/Integrated (Wnt), and yes-associated protein 1 (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) signaling pathways (Figure 1) (Piersma et al., 2015