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doi: 10.3233/JPD-181503 65 MulvaneyCADuarteGSHandleyJEvansDJMenonSWyseRet al

Clinical trials have been conducted to assess the efficacy of ghrelin as a novel therapeutic target in various disorders such as anorexia, cachexia, functional gastrointestinal disorders, gastroparesis, and gastrointestinal cancers (1216)

Although the precise molecular mechanisms of the NLRP3 inflammasome activation remain to be fully elucidated, reactive oxygen species (ROS) are widely regarded as essential for NLRP3 inflammasome activation (111)