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Conclusions Among adults with HIV on ART and lipohypertrophy, semaglutide (GLP-1) slowed DNA methylation aging across PCGrimAge, PhenoAge, DunedinPACE, and organ clocks, while IC was unchanged
Starting any GLP-1 therapycompounded or brandeddemands baseline labs, informed consent about gastrointestinal side effects, and regular follow-up monitoring for safety and efficacy
Following RNase treatment and denaturation, serially diluted DNA was spotted on Hybond-N + membranes (#RPN203B, Amersham Biosciences)
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