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The current work is predicated on previous suggestions that GLP-1 activity depends on adoption of a reverse turn near the peptide N-terminus, which raises the possibility that the N-terminal helical conformation in the cryo-EM structure of receptor-bound GLP-1 12 may not fully capture structural requirements for signaling

Peptide hormones as ingredients in supplements

[DOI] [PubMed] [Google Scholar] 18.Juhl CB, Hollingdal M, Sturis J, Jakobsen G, Agers H, Veldhuis J, et al

These agents target multiple metabolic pathways involved in appetite regulation, insulin secretion, glucose homeostasis, and energy expenditure, making them particularly relevant for adolescents with obesity and associated metabolic complications