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Additionally, the study by Lundgren et al

To view a copy of this licence, visit About this article Cite this article Hashimoto, S., Matsuba, Y., Takahashi, M

Among them, HLA alleles, especially the HLA-DR1 and HLA-DR4 loci, play an important role in the development of RA by mechanisms that may be related to the formation of citrullinated antigens and immune tolerance of CD4 + T cells (Wysocki et al., 2020