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A primary concern in the initial evaluation is the identification or exclusion of adrenal insufficiency, as it represents the only clinical scenario necessitating immediate, life-saving hormone replacement therapy [147]

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Given these concerns, the American Society of Anesthesiologists (ASA) Task Force on Preoperative Fasting has issued a consensus-based guidance for management of GLP-1 receptor agonists prior to elective surgery

The absence of detectable mutations in these patients may be due to the limitations of current high-throughput sequencing techniques, which primarily target exonic regions and the surrounding 20 base pairs of intronic sequences, potentially overlooking deep intronic and promoter region variations