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Post-mortem evaluation of hippocampal formation and cerebral cortex tissue demonstrates dysfunctional insulin signaling in AD with elevated basal levels of IRS1 serine phosphorylation and reduced insulin-stimulated levels of downstream signaling molecules [94]

CrossRef Harnessing Gut MicrobiomeBrainLiver Crosstalk: Novel Therapeutic Strategies for Metabolic DysfunctionAssociated Steatotic Liver Disease Xingtao Zhao, Ruolan Li, Jingdong Zhao, Ruiqi Sun, Shuo Zhang, Qiong Pan, Hongyan Lu, Jin Chai Medicine Bulletin .2025

In the OASIS 4 trial, 7% of participants discontinued treatment due to side effectscomparable to rates seen with injectable formulations

The theoretical rationale centers on several observations