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As a signaling molecule, GLP-1 increases the bodys sensitivity to insulin, the hormone responsible for controlling blood sugar levels

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Nausea is the most common side effect, particularly during dose escalation phases Vomiting, diarrhoea, and decreased appetite were also frequently reported Side effects typically peaked early and diminished over weeks at each dose level Dose holds rather than discontinuation are recommended for tolerability issues Dietary adjustments significantly reduce the impact of GI side effects How Retatrutide Compares to Other Weekly Injectables Placing retatrutide in context alongside currently available weekly injectables helps to illustrate why there is such widespread anticipation around its eventual approval

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