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Taken together, these limitations highlight the urgent need for updated frameworks that transcend reductionist approaches and integrate genomic, metagenomic, biochemical, nutritional, and lifestyle dimensions into a comprehensive precision-medicine strategy for neurodegeneration

For instance, it has been shown that after an experimental psychologic stress, the evoked cortisol response in fatigued breast cancer survivors is much smaller than that in nonfatigued ones, pointing to the involvement of the HPA axis in cancer-related fatigue (286)

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